- Disseminated histoplasmosis in a late post-liver transplant recipient: a case report and literature review. [Case Reports]Einstein (Sao Paulo). 2026; 24:eRC1988.E
- Histoplasmosis is an endemic mycosis in certain regions of Brazil and represents a rare opportunistic infection in solid organ transplant recipients. This report describes the case of a 68-year-old female liver transplant recipient (due to Caroli disease) who presented with abdominal pain, nausea, vomiting, and a distended, tender abdomen. Abdominal computed tomography revealed parietal thickenin…
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- Auricular Acupressure for Managing Nausea-Vomiting, Pain and Fatigue After Liver Arterial Chemoembolization and Hepatic Arterial Infusion Chemotherapy. [Journal Article]J Vis Exp. 2026 Aug 18; (234).JV
- Patients undergoing transarterial chemoembolization or hepatic arterial infusion chemotherapy frequently experience nausea, vomiting, pain, fatigue, sleep disturbance, and appetite loss during hospitalization, yet standardized nonpharmacologic supportive care protocols remain limited. This study aimed to describe a standardized auricular acupressure protocol integrated into peri-interventional nu…
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- Comparison of oral tizanidine and baclofen for post-operative pain management after femoral fracture surgery. [Randomized Controlled Trial]J Opioid Manag. 2026; 22(3):279-287.JO
- CONCLUSIONS: Preoperative administration of 4 mg tizanidine and 25 mg baclofen showed comparable efficacy in post-operative pain management. As this study lacked a placebo control, it cannot confirm the absolute analgesic efficacy of either drug over no treatment. Although tizanidine demonstrated a trend toward lower pain scores at certain intervals, these differences were not statistically significant after adjustment for multiple comparisons. Both drugs exhibited similar safety profiles and supplemental analgesic requirements.
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- Management of post-operative pain by metoclopramide in patients undergoing cesarean section: A double-blinded randomized clinical trial. [Randomized Controlled Trial]J Opioid Manag. 2026; 22(3):269-277.JO
- CONCLUSIONS: Metoclopramide significantly reduced early post-operative pain and opioid requirements, with reductions exceeding minimal clinically important difference thresholds. While statistically robust, these benefits should be weighed against its transient antiemetic effects and the need for larger trials to confirm functional recovery benefits.
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- Association of preoperative state anxiety and early postoperative recovery in living kidney donors undergoing nephrectomy: A prospective observational study. [Journal Article]J Anesth Transl Med. 2026 Sep; 5(3):171-178.JA
- CONCLUSIONS: Higher preoperative state anxiety scores were associated with lower early postoperative recovery scores, greater early postoperative pain, longer hospital stay, and lower patient satisfaction among living kidney donors.
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- Effect of virtual reality-integrated mindfulness-based cognitive therapy on pain and psychological symptoms in chronic non-specific low back pain: protocol for a randomized controlled trial. [Journal Article]Front Digit Health. 2026; 8:1902063.FD
- Chronic non-specific low back pain (CNLBP) is a common condition associated with persistent pain, functional limitation, reduced quality of life, and substantial healthcare and socioeconomic burden. Mindfulness-based cognitive therapy (MBCT) has been increasingly used in chronic pain management and may provide a promising therapeutic approach for CNLBP. The emergence of virtual reality (VR) furth…
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- Refractory Intraprocedural Ventricular Fibrillation From Left Circumflex Culprit Occlusion Managed With Culprit PCI and Short-Duration Impella Support. [Journal Article]Case Rep Cardiol. 2026; 2026:2641470.CR
- Ventricular fibrillation (VF) is a life-threatening complication of acute coronary syndrome (ACS) and requires rapid identification and correction of reversible ischemic triggers. ST-segment elevation in aVR with diffuse ST depression reflects global subendocardial ischemia but is not specific for left main or proximal left anterior descending disease.
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- A pharmacoeconomic evaluation of aprepitant injection versus aprepitant capsules for the prevention of CINV caused by moderately and highly emetogenic chemotherapy. [Journal Article]Front Pharmacol. 2026; 17:1879202.FP
- CONCLUSIONS: Aprepitant injection and aprepitant capsules showed no statistically significant differences in efficacy, safety, or quality-of-life outcomes in this matched retrospective cohort. However, aprepitant injection demonstrated superior pharmacoeconomic performance through lower antiemetic drug costs, reduced total hospitalization expenditures, and more favorable economic outcomes. From a healthcare resource utilization perspective, aprepitant injection may represent a more cost-effective prophylactic antiemetic strategy and could provide useful evidence for individualized clinical decision-making and reimbursement policy optimization.
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- Opioid type, rather than liver function, is associated with postoperative nausea and vomiting after painless gastroscopy in decompensated cirrhosis. [Journal Article]Front Pharmacol. 2026; 17:1865501.FP
- CONCLUSIONS: Preoperative albumin, total bilirubin and Apfel score did not independently predict PONV. Alfentanil was independently associated with a significantly reduced risk of PONV compared to nalbuphine. Postoperative liver function changes were mild, similar between groups and unrelated to PONV. Our findings are hypothesis-generating and require confirmation in larger studies.
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- Comparing chemotherapy-induced nausea and vomiting between young adult vs non-young adult cancer patients. [Journal Article]JNCI Cancer Spectr. 2026 Aug 18. [Online ahead of print]JC
- Chemotherapy-induced nausea and vomiting (CINV) are among the most distressing side effects of cancer therapy. Younger age is a risk factor for CINV, and cancer incidence is rising among young adults (YAs) ages 18-39. However, the comparative burden of CINV in YAs versus non-YAs remains insufficiently understood. This study compared acute and delayed CINV between YAs and non-YAs (i.e., ages ≥40) …
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- Ginger in supportive therapy against side effects of oncological treatment: a systematic review. [Systematic Review]BMC Complement Med Ther. 2026 Aug 18; 26(1).BC
- CONCLUSIONS: Ginger can be considered a promising candidate for complementing the supportive therapy against the side effects of cancer treatment of oncological patients. The data on this is still limited due to heterogeneous results and methodical limitations of the included studies.
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- Using GLP-1 Receptor Agonists in Patients with Inflammatory Bowel Disease: A Systematic Review and Single-Arm Meta-Analysis. [Systematic Review]Dig Dis. 2026 Aug 18; :1-24. [Online ahead of print]DD
- CONCLUSIONS: Our findings suggest that GLP-1 RAs may be promising for reducing weight and improving metabolic parameters without exacerbating activity, and may be a safe option for IBD patients. However, larger randomized controlled trials are needed to assess causal inference and long-term effects.
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- Diagnostic Twists and Turns: Spotting an Isolated Fallopian Tube Torsion. [Case Reports]Ultrasound Q. 2026 Sep 01; 42(3).UQ
- Isolated fallopian tube torsion (IFTT) is a rare form of adnexal torsion. A 2024 review described fewer than 150 cases over several decades. The clinical presentation of IFTT is highly variable and nonspecific, which may result in delayed diagnosis. Most patients present with acute unilateral abdominal pain with nausea and/or vomiting, while other patients may present with more gradual symptoms. …
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- Antiemetic Combination Use During the First Trimester and Adverse Circulatory Outcomes in Newborn Infants: A Data-Mining Analysis. [Journal Article]Drug Saf. 2026 Aug 18. [Online ahead of print]DS
- CONCLUSIONS: By scanning more than 300 infant circulatory-related outcomes, we identified unspecified hypotension as a potential safety signal among newborns whose mothers were exposed to promethazine-ondansetron combination rather than metoclopramide-ondansetron combination during the first trimester. This finding warrants further investigation and illustrates the utility of tree-based scan statistics as a hypothesis-generating tool for pregnancy medication safety research.
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- Palonosetron-induced anaphylaxis during general anesthesia in a patient with multiple drug hypersensitivity. [Journal Article]Int J Clin Pharmacol Ther. 2026 Aug 18. [Online ahead of print]IJ
- CONCLUSIONS: Prior uneventful exposure to palonosetron does not guarantee future safety. Atopic patients with polysensitization are at significantly increased risk of severe anaphylaxis upon re-exposure. Positive ondansetron skin testing provides indirect evidence identifying palonosetron as the culprit. All 5-HT3 receptor antagonists should permanently be avoided in such patients, and alternative antiemetics (e.g., dexamethasone, droperidol, NK1 antagonists) should be selected.
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