Remnant cholecystitis caused by cystic duct stones is a rare cause of post-cholecystectomy syndrome and it is often difficult to diagnose. We report the case of a man in his seventies with recurrent epigastric pain one year after laparoscopic cholecystectomy. Computed tomography revealed a 10-mm cystic duct stone. Endoscopic retrograde cholangiography (ERC) demonstrated macroscopic purulent bile from the remnant cystic duct, whereas bile from the common bile duct was grossly normal. This confirmed the diagnosis of localized remnant cholecystitis, without the need for cholangioscopy. ERC-guided drainage and subsequent stone removal resulted in a complete recovery. To the best of our knowledge, this is the first report demonstrating macroscopic bile differentiation and successful treatment with ERC-alone.

Acute cholangitis is a potentially life-threatening condition commonly caused by bacterial infections of the biliary tract. Here, we present an unusual case of acute cholangitis caused by Vibrio cholerae in a 76-year-old man with a history of hypertension, diabetes, asthma, and post-cholecystectomy who presented with upper abdominal pain, jaundice, and fatigue. Lab results showed elevated inflammatory markers and bilirubin. Imaging revealed gallstones and bile duct dilation. Blood cultures isolated non-toxigenic Vibrio cholerae, which was highly susceptible to all tested antibiotics. The patient was successfully treated with piperacillin/tazobactam and levofloxacin, along with supportive care. His symptoms resolved, and subsequent cultures were negative. This case highlights a rare instance of non-cholera Vibrio cholerae causing acute cholangitis and bacteremia in an elderly patient.

Titanium is widely regarded as a biocompatible and inert material commonly used in surgical implants. Despite this reputation, hypersensitivity reactions to titanium, though rare, can lead to persistent and unexplained postoperative symptoms. We report the case of a 76-year-old woman who developed progressive right upper quadrant abdominal pain, burning sensations, neuropathic symptoms, and fatigue three months after laparoscopic cholecystectomy in which titanium clips were used. Her history included documented systemic intolerance to a titanium dental implant 10 years earlier, which had required removal. Extensive laboratory and imaging evaluation was unremarkable. Titanium hypersensitivity was clinically suspected based on the temporal association between clip placement and symptom onset, along with systematic exclusion of alternative causes. MELISA® (memory lymphocyte immunostimulation assay) testing was discussed, but declined due to cost and extended turnaround time. Following diagnostic laparoscopy and removal of the four titanium clips approximately three months after symptom onset, the patient experienced complete symptom resolution within one week. She remains asymptomatic at six-month follow-up. This case highlights the importance of considering metal hypersensitivity in patients with unexplained postoperative symptoms and prior exposure to implants. Increased awareness and selective preoperative screening, particularly evaluation for prior metal intolerance, may help prevent unnecessary morbidity and repeated interventions.

Biliary peritonitis, also known as choleperitoneum, is a rare but severe complication of cholecystectomy. The symptoms are non-specific, which can cause a delay in the diagnosis, leading to potential sepsis and multi-organ failure. A 45-year-old female underwent robotic cholecystectomy for gallstone pancreatitis and cholecystitis. One week post-operatively, she presented again with abdominal pain and distention, rapidly progressing to septic shock with respiratory, renal, and neurological failure. Initial imaging showed only mild ascites. Imaging showed a biliary leak, and paracentesis confirmed a biliary peritonitis by revealing bilious fluid (ascitic bilirubin 25 mg/dL). The patient underwent endoscopic retrograde cholangiopancreatography (ERCP) with biliary stent placement and was started on antibiotics, with improvement in clinical condition. The case highlights the diagnostic difficulty of choleperitoneum, where early imaging can be subtle. Timely, multidisciplinary management involving peritoneal drainage, ERCP with stent placement, and prophylactic antibiotics is necessary; otherwise, biliary peritonitis is associated with significant mortality and morbidity. This report underscores the need for vigilance even after technically uneventful surgery, particularly in high-risk patients.

BackgroundBenign biliary and pancreatic diseases, including postoperative strictures, bile leaks, and chronic pancreatitis, often require temporary ductal decompression with plastic or metal stents, which may necessitate repeat interventions due to occlusion, migration, or removal. Biodegradable stents (BDSs) have emerged as an alternative, providing temporary support with spontaneous degradation and avoiding retrieval.MethodsA systematic search of PubMed, EMBASE, MEDLINE, Scopus, and the Cochrane Library was conducted to May 22, 2025, in accordance with PRISMA guidelines. Eligible studies reported human data on BDS use for benign biliary or pancreatic disease. Outcomes included technical and clinical success, dwell time, complications, and reintervention.ResultsFifteen studies (467 patients) were included. The most frequent indication was benign biliary stricture, followed by post-cholecystectomy bile leaks and pancreatic duct strictures. Stents were placed via ERCP (n = 193) or percutaneous transhepatic cholangiography (n = 274). Polydioxanone-based devices were most common, with diameters 2-12 mm and lengths 30-125 mm. Technical success was 99.4% and clinical success 73.3%. Across studies, 108 complications were reported, most often cholangitis (n = 36), stricture recurrence (n = 19), haemobilia/bleeding (n = 16), and pain/fever (n = 11); migration and pancreatitis were less frequent. The mean reintervention rate was 35.5% (range 0-100%), largely reflecting planned management after stent degradation rather than device failure. Mean follow-up was 14.4 months (range 0.5-52).ConclusionsBDSs appear safe and effective in selected benign biliary and pancreatic conditions. Further prospective studies and randomized trials are needed to establish optimal indications and long-term outcomes.

Post-cholecystectomy clip migration is a rare but significant complication of laparoscopic cholecystectomy that can manifest years after the initial surgery. We report the case of a 56-year-old female who presented with chronic upper abdominal pain, nausea, and vomiting eight years following laparoscopic cholecystectomy. Laboratory investigations demonstrated markedly elevated liver enzyme levels, and imaging studies revealed a stone in the common bile duct. Endoscopic retrograde cholangiopancreatography identified a surgical clip embedded within the stone, serving as a nidus for stone formation. Successful treatment was achieved through biliary sphincterotomy and stone retrieval, resulting in complete symptomatic relief and normalization of liver function tests. This case highlights the importance of considering clip migration as a potential etiology in post-cholecystectomy patients presenting with unexplained biliary symptoms, even many years after the initial surgical procedure.

Surgical clip migration is a rare but important cause of delayed postcholecystectomy complications. An 83-year-old man presented 8 years after laparoscopic cholecystectomy with abdominal pain and jaundice. Imaging showed biliary dilation with a 20-mm common bile duct stone. Endoscopic retrograde cholangiopancreatography with cholangioscopy identified a migrated surgical clip serving as the nidus. Electrohydraulic lithotripsy achieved fragmentation, followed by balloon extraction and placement of a fully covered metal stent. The patient recovered uneventfully. This case highlights the need to consider clip migration in patients with late-onset biliary obstruction after cholecystectomy and supports cholangioscopy-guided lithotripsy as a definitive therapy.

We present the case of a 60-year-old woman who was admitted with acute pancreatitis, cholelithiasis, and cholecystitis, and subsequently underwent an uneventful laparoscopic cholecystectomy. Two weeks postoperatively, she returned to the hospital with severe epigastric pain radiating to the back, accompanied by nausea and vomiting. Contrast-enhanced computed tomography (CT) imaging revealed acute necrotizing pancreatitis with early pancreatic pseudocyst formation at the junction of the pancreatic body and tail, without evidence of biliary obstruction or retained stones. She was managed with intravenous fluids, broad-spectrum antibiotics, bowel rest, analgesia, and underwent endoscopic retrograde cholangiopancreatography (ERCP) with pancreatic duct stent placement to reduce ductal pressure. She improved clinically and was discharged after one week of hospitalization, but returned two weeks later with signs of sepsis. Pancreatic pseudocysts are rare complications of pancreatitis, more often associated with chronic cases, and typically develop several weeks after inflammation or ductal injury. Their occurrence following an uncomplicated cholecystectomy in the absence of biliary obstruction or retained stones is exceptionally uncommon. This case underscores the diagnostic and management challenges of post-cholecystectomy pancreatitis complicated by pseudocyst formation and highlights the importance of interval imaging, multidisciplinary evaluation, and conservative management in stable patients. Awareness of this rare complication is essential to prevent unnecessary interventions while ensuring timely escalation of care when indicated.

Laparoscopic cholecystectomy is the gold standard treatment of symptomatic gallstone disease. Persistent symptoms post-cholecystectomy are typically caused by a variety of pathological entities such as gastrointestinal or biliary disorders. Cholecystitis, cholelithiasis, choledocholithiasis and cholangitis are among the rare etiologies of recurrent gallstone disease that can occur after cholecystectomy. Herein, we report a rare case of remnant gallbladder cholecystitis and cholelithiasis in a 67-year-old patient who presented with acute abdominal pain following laparoscopic cholecystectomy. We review the literature on this rare entity and highlight the significance of having a high clinical index of suspicion and using the preferred diagnostic imaging modality. We also provide details about the definitive management of this entity.

A 42-year-old male presented with a two-month history of right upper quadrant abdominal pain, worsening over four days. Six months earlier, he had undergone a laparoscopic cholecystectomy. Examination revealed no jaundice or tenderness, and liver function tests were normal. The patient's basic inflammatory markers were within the normal range. Ultrasound revealed a residual gallbladder stump or dilated cystic duct with a calculus, and magnetic resonance cholangiopancreatography (MRCP) demonstrated a 3 × 1 cm stump with an 8 mm hypointense focus. Endoscopic retrograde cholangiopancreatography (ERCP) was unsuccessful due to distorted anatomy. Surgical exploration confirmed a cystic duct remnant containing sludge and concretions, which was excised completely. Postoperative recovery was uneventful, and histopathology revealed chronic inflammatory changes consistent with cystic duct stump pathology. This case illustrates that residual gallbladder stump cholelithiasis may occur after laparoscopic cholecystectomy. Recognition of this possibility, along with appropriate imaging, enables timely diagnosis. Surgical excision of the cystic duct remnant provides definitive treatment and effective symptom relief in patients with post-cholecystectomy syndrome caused by residual ductal concretions.

Mirizzi syndrome (MS) is an uncommon complication of gallstone disease in which an impacted stone in the cystic duct or gallbladder neck leads to external compression of the common bile duct (CBD). Its clinical and imaging features often mimic other hepatobiliary conditions, making preoperative diagnosis challenging and increasing the risk of biliary injury. We report the case of a 34-year-old male who presented with sudden-onset right upper quadrant pain. His history of gallstones and examination findings suggested acute calculous cholecystitis. Laboratory tests revealed elevated liver enzymes, while abdominal ultrasound demonstrated gallstones without CBD dilation. He underwent a laparoscopic cholecystectomy on hospital day three. Intraoperative findings included a distended gallbladder with a dilated cystic duct and CBD. Postoperative magnetic resonance cholangiopancreatography (MRCP) revealed a long cystic duct stump with an impacted stone causing compression of the CBD and proximal biliary dilation, consistent with MS. Subsequent endoscopic retrograde cholangiopancreatography (ERCP) confirmed the diagnosis, and sphincterotomy with CBD stenting was performed. The patient recovered uneventfully and remained stable on follow-up. This case underscores the importance of maintaining a high index of suspicion for MS, particularly in patients with gallstones presenting with atypical features or persistent biliary dilation. Early identification and multidisciplinary management are crucial for preventing complications and ensuring optimal outcomes.