Coital urinary incontinence (CUI), defined as involuntary urine leakage during or after sexual activity, is a common yet underreported condition affecting both women and men, with significant effects on emotional wellbeing, sexual satisfaction and intimate relationships. This article reviews the evidence on the prevalence, pathophysiology and management of CUI in women and men, and outlines key clinical considerations for nursing practice. In women, CUI may occur at penetration, during intercourse, or at orgasm, often linked to stress, mixed, or urgency urinary incontinence and pelvic floor dysfunction. In men, CUI is frequently associated with prostate surgery, particularly following treatment for prostate cancer, where sphincter and pelvic floor impairment contribute to leakage. Despite its prevalence, stigma often prevents open discussion. Effective management includes pelvic floor muscle exercises, behavioural modifications, pharmacological treatments and, in some cases, surgery. Health professionals play a critical role in normalising conversations, identifying symptoms, and providing holistic, evidence-based care. Addressing both the physical and psychosocial aspects of CUI can improve quality of life and help individuals regain confidence and intimacy.

Pelvic floor disorders, including pelvic organ prolapse and urinary incontinence, represent a common health burden with substantial clinical comorbidity, but their shared genetic architecture remains incompletely understood. We performed a multi-trait genomic analysis of six pelvic-floor-related phenotypes using publicly available GWAS summary statistics from FinnGen R12 and the GWAS Catalog, with Pan-UKBB summary statistics used only for cross-ancestry validation. Linkage disequilibrium score regression and Genomic Structural Equation Modeling identified two broad latent genetic dimensions: a structural factor related to anatomical prolapse and a functional factor related to urinary and bowel dysfunction. MAGMA gene-based analysis identified 267 significant genes enriched for extracellular matrix organization and urogenital developmental pathways, including WNT4, LOXL1, ESR1, WT1, HNF1B, and FGFR2. An exploratory network-informed machine-learning framework incorporating protein-protein interaction topology improved gene prioritization over a baseline Random Forest model and highlighted biologically plausible hub genes. Cross-ancestry analysis of Pan-UKBB female genital prolapse supported directional portability of European-discovered signals and identified WNT4 as a directionally concordant locus. These findings provide a systems-level map of pelvic-floor-related genetic architecture and prioritize candidate genes for future functional validation.