Infections in the pregnant and recently pregnant woman pose many challenges to the OB/GYN hospitalists. Pregnancy can alter the presentation, diagnosis, and management of severe maternal infections. For example, use of the standard clinical criteria to diagnose sepsis in the intensive care unit would result in inappropriate interventions in 12% of laboring patients. Sepsis, defined as life-threatening organ dysfunction due to a dysregulated host response to infection, can be differentiated into various entities: systemic inflammatory syndrome (SIRS), sepsis, and septic shock depending on which criteria are met.[1] Use of current pregnancy-specific screening guidelines is recommended to better reflect the disease spectrum.