Surgical site infection is the most common complication of gynecologic surgery and occurs in up to 28% of unscheduled cesarean deliveries. Complications include delayed or abnormal healing, wound breakdown, wound infections, seroma, and hematoma. Management of wound complications varies and may include observation, secondary intention healing, aggressive debridement, and antibiotics for necrotizing fasciitis. OB/GYN hospitalists are positioned to initiate early recognition and treatment of surgical site infections. OB/GYN hospitalists also assist in prevention of surgical site infection by ensuring that appropriate evidence-based prophylactic measures such as preoperative and intraoperative antibiotics, adequate abdominal and vaginal preparation, appropriate surgical approach, and proper wound closure are implemented for every patient.