Placenta accreta spectrum describes the pathologic diagnosis of placental invasion into the uterus or invading through the uterine serosa into surrounding pelvic structures. This diagnosis encompasses the placenta accreta, increta, and percreta. Placenta accreta spectrum is associated with significant maternal morbidity due to the risk of hemorrhage and possible hysterectomy. In addition, this condition carries up to a 5% to 7% risk of maternal mortality.[1] Placenta previa with 1, 2, or 3 prior cesarean deliveries increases the risk of placenta accreta spectrum to 11%, 40%, and 60%, respectively.[2] Prenatal ultrasonography is the primary diagnostic modality, but MRI can be useful in certain settings. Women with placenta accreta spectrum should be managed by a multidisciplinary care team. Cesarean hysterectomy is traditionally the treatment of choice, but other options include surgical resection, delayed hysterectomy, and other uterine-sparing techniques. Delivery is often recommended between 34 to 36 weeks’ gestation to maximize neonatal outcomes and minimize third-trimester bleeding risk. OB/GYN hospitalists can serve as critical members of the multidisciplinary care team in either a primary or surgical support role. OB/GYN hospitalists can promote best practice by recognizing the risk factors of placenta accreta spectrum and assisting in mobilizing the multidisciplinary care team when delivery is necessary.