Complementary/Alternative Medicine: This monograph describes a natural or herbal product that is not subject to FDA guidelines for medicines. Patients and clinicians are advised to read package labels carefully to ensure safe and efficacious use.
erectile dysfunction agents
Yohimbine causes genital blood vessel dilation, nerve impulse transmission to genital tissue, and increased reflex excitability in the sacral region of the spinal cord. It works primarily through alpha 2–adrenergic receptor blockade and also has monoamine oxidase inhibiting, calcium channel blocking, and serotonin receptor blocking effects.
Improved sexual function.
Metabolism and Excretion: Unknown
Use Cautiously in:
CV: hypertension, tachycardia, cardiac failure (high doses)
CNS: excitation, headache, tremor, anxiety, dizziness, insomnia
F and E: fluid retention
GI: nausea, vomiting
GU: urinary frequency
MS: paralysis (high doses)
Misc: hypersensitivity reactions
Resp: respiratory depression (high doses)
* CAPITALS indicate life-threatening.
Underline indicate most frequent.
Natural Drug Interaction
Increased risk of alpha 2–adrenergic antagonism with phenothiazines..Increased risk of hypertensive crisis with stimulants..
Concomitant use with caffeine-containing herbsand ephedra can cause hypertensive crisis.
PO (Adults): 15–30 mg/daily. Doses up to 100 mg/day have been used but with significantly more side effects.
Capsules: 2.5 mg, 3 mg
Male erection sufficient to allow intercourse.
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