Concurrent use of constipating drugs such asalosetron, anticholinergics (including loperamide) and opioids ↑ risk of constipation and its sequelae; avoid chronic concurrent use.
May ↑ levels and risk of myopathy/rhabdomyolysis with rosuvastatin; use lowest effective dose of rosuvastatin.
May ↑ levels and risk of toxicity with alfentanil, cyclosporine, dihydroergotamine, ergotamine, fentanyl, pimozide, quinidine, sirolimus, and tacrolimus; careful blood level/clinical monitoring recommended.
PO (Adults) 100 mg twice daily; Patients who lack a gallbladder, are unable to tolerate 100 mg twice daily or are taking concurrent OATP1B1 inhibitors–75 mg twice daily.Hepatic Impairment (Adults) Mild-moderate hepatic impairment–75 mg twice daily.
Tablets: 75 mg, 100 mg
Assess bowel function (quality and quantity of stools) periodically during therapy. Discontinue eluxadoline if constipation last more than 4 days.
Instruct patient to take eluxadoline as directed. If a dose is missed, omit and take next dose as scheduled; do not double doses.
Advise patient that eluxadoline is a drug with known abuse potential. Protect it from theft, and never give to anyone other than the individual for whom it was prescribed.
Advise patient to stop eluxadoline and notify health care professional if abdominal pain (acute epigastric or biliary [right upper quadrant] pain), may radiate to back or shoulder with or without nausea and vomiting) occur.
Caution patient to avoid more that 3 alcoholic drinks/day.
Advise patient to notify health care professional of all Rx or OTC medications, vitamins, or herbal products being taken and consult health care professional before taking any new medications, especially other medications causing constipation.
Advise female patient to notify health care professional of pregnancy is planned or suspected or if breastfeeding.
Reduction of abdominal pain/diarrhea in patients with irritable bowel syndrome.
eluxadoline is a sample topic from the Davis's Drug Guide.
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