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- FN is defined as an absolute neutrophil count (ANC) of <500/μL, with a single core temperature of >38.3°C or a persistent temperature (>1 hour) of >38.0°C.
- Risk of FN is proportional to the duration of neutropenia.
- Although most solid tumor chemotherapy regimens are associated with a brief (<5 days) duration of neutropenia, neutropenia with leukemia and transplantation regimens can be more persistent.
- Risk is also increased with regimens that cause mucositis (inflammation and ulceration of the oral and GI mucosa).
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