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Normal hemostasis involves a sequence of interrelated reactions that lead to platelet aggregation (primary hemostasis) and activation of coagulation factors (secondary hemostasis) to produce a durable vascular seal.
Solid arrows indicate activation. Solid or dashed lines that run into a vertical line are associated with drugs represent a point of inhibition. Extrinsic pathway includes the right upper portion of cascade above factor X. Intrinsic pathway includes the left upper portion of the cascade above factor X. Common pathway includes the lower portion of the cascade from factor X and below. AT, antithrombin; LMWH, low-molecular-weight heparin; TF, tissue factor.
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Normal hemostasis involves a sequence of interrelated reactions that lead to platelet aggregation (primary hemostasis) and activation of coagulation factors (secondary hemostasis) to produce a durable vascular seal.
Solid arrows indicate activation. Solid or dashed lines that run into a vertical line are associated with drugs represent a point of inhibition. Extrinsic pathway includes the right upper portion of cascade above factor X. Intrinsic pathway includes the left upper portion of the cascade above factor X. Common pathway includes the lower portion of the cascade from factor X and below. AT, antithrombin; LMWH, low-molecular-weight heparin; TF, tissue factor.
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