Cushing Syndrome

Cushing Syndrome is a topic covered in the Washington Manual of Medical Therapeutics.

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General Principles

  • Cushing syndrome is most often iatrogenic because of therapy with glucocorticoid drugs.
  • ACTH-secreting pituitary microadenomas (Cushing disease) account for 80% of cases of endogenous Cushing syndrome.
  • Adrenal tumors and ectopic ACTH secretion account for the remainder.

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General Principles

  • Cushing syndrome is most often iatrogenic because of therapy with glucocorticoid drugs.
  • ACTH-secreting pituitary microadenomas (Cushing disease) account for 80% of cases of endogenous Cushing syndrome.
  • Adrenal tumors and ectopic ACTH secretion account for the remainder.

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