Superior Vena Cava Syndrome

Superior Vena Cava Syndrome is a topic covered in the Washington Manual of Medical Therapeutics.

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Washington Manual

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  • Cancer-related SVC syndrome results from obstruction of blood flow through the SVC through invasion, external compression, or thrombosis in the setting of a malignancy.
  • The severity and rapidity of symptom onset depends on the rate at which the SVC is occluded and if there has been enough time for collateral venous drainage to develop.
  • Lung cancer, lymphomas, thymic neoplasms, germ cell tumors, mesothelioma, and other solid tumors that cause mediastinal involvement are the cancers that are commonly associated with SVC syndrome.

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