Thrombocytosis
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General Principles
Definition
Thrombocytosis is defined as a platelet count of >450 × 109/L by the World Health Organization (WHO).
Etiology
Thrombocytosis has reactive and clonal etiologies that may coexist.
- Reactive thrombocytosis may occur during recovery from thrombocytopenia; after splenectomy; or in response to iron deficiency, acute infectious or chronic inflammatory states, trauma, and malignancies.
- Low risks of thrombosis or bleeding.
- Platelets normalize after improvement of the underlying disorder.
- If accompanied by thrombotic complications, evaluate for an underlying myeloproliferative disorder.
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General Principles
Definition
Thrombocytosis is defined as a platelet count of >450 × 109/L by the World Health Organization (WHO).
Etiology
Thrombocytosis has reactive and clonal etiologies that may coexist.
- Reactive thrombocytosis may occur during recovery from thrombocytopenia; after splenectomy; or in response to iron deficiency, acute infectious or chronic inflammatory states, trauma, and malignancies.
- Low risks of thrombosis or bleeding.
- Platelets normalize after improvement of the underlying disorder.
- If accompanied by thrombotic complications, evaluate for an underlying myeloproliferative disorder.
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