Hemophilia A

Hemophilia A is a topic covered in the Washington Manual of Medical Therapeutics.

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General Principles

Definition

Hemophilia A is an X-linked recessive coagulation disorder due to mutations in the gene encoding factor VIII.

Epidemiology

Hemophilia A affects ∼1 in 5000 live male births. Approximately 40% of cases occur in families with no prior history of hemophilia, reflecting the high rate of spontaneous germline mutations in the factor VIII gene.1

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General Principles

Definition

Hemophilia A is an X-linked recessive coagulation disorder due to mutations in the gene encoding factor VIII.

Epidemiology

Hemophilia A affects ∼1 in 5000 live male births. Approximately 40% of cases occur in families with no prior history of hemophilia, reflecting the high rate of spontaneous germline mutations in the factor VIII gene.1

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