Hemophilia A
To view the entire topic, please log in or purchase a subscription.
The Washington Manual of Medical Therapeutics helps you diagnose and treat hundreds of medical conditions. Consult clinical recommendations from a resource that has been trusted on the wards for 50+ years. Explore these free sample topics:
-- The first section of this topic is shown below --
General Principles
Definition
Hemophilia A is an X-linked recessive coagulation disorder due to mutations in the gene encoding factor VIII.
Epidemiology
Hemophilia A affects ∼1 in 5000 live male births. Approximately 40% of cases occur in families with no prior history of hemophilia, reflecting the high rate of spontaneous germline mutations in the factor VIII gene.1
-- To view the remaining sections of this topic, please log in or purchase a subscription --
General Principles
Definition
Hemophilia A is an X-linked recessive coagulation disorder due to mutations in the gene encoding factor VIII.
Epidemiology
Hemophilia A affects ∼1 in 5000 live male births. Approximately 40% of cases occur in families with no prior history of hemophilia, reflecting the high rate of spontaneous germline mutations in the factor VIII gene.1
There's more to see -- the rest of this entry is available only to subscribers.