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Nausea

Nausea is a topic covered in the Washington Manual of Medical Therapeutics.

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  • Historically, nausea was one of the most debilitating side effects of chemotherapy. The advent and use of effective antiemetic therapies have made chemotherapy much more tolerable for cancer patients.
  • Incidence of chemotherapy-induced nausea and vomiting (CINV) is widely variable and depends on both drug and dose used.
  • CINV can be categorized as acute (<24 hours) or delayed (>24 hours). Acute CINV is an important predictor of delayed CINV.
  • Prevention of CINV is more effective than treatment. Commonly used prophylactic agents include:
    • Dexamethasone, which has active antiemetic properties. It is frequently administered via IV before chemotherapy (premedication) and continued orally for 2–3 days with certain chemotherapy regimens.
    • 5-Hydroxytryptamine-3 (5-HT3) receptor antagonists (ondansetron, granisetron, dolasetron, palonosetron), which are highly effective and widely used as premedications.
    • Aprepitant, which is used with highly emetogenic regimens.
    • Olanzapine, an antipsychotic agent, is also effective in preventing and managing CINV associated with highly emetogenic regimens.

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Citation

Williams, Dominique, et al., editors. "Nausea." Washington Manual of Medical Therapeutics, 35th ed., Wolters Kluwer Health, 2016. Washington Manual, www.unboundmedicine.com/washingtonmanual/view/Washington-Manual-of-Medical-Therapeutics/602038/all/Nausea.
Nausea. In: Williams D, Ramgopal R, Gdowski M, et al, eds. Washington Manual of Medical Therapeutics. 35th ed. Wolters Kluwer Health; 2016. https://www.unboundmedicine.com/washingtonmanual/view/Washington-Manual-of-Medical-Therapeutics/602038/all/Nausea. Accessed July 20, 2019.
Nausea. (2016). In Williams, D., Ramgopal, R., Gdowski, M., Dretler, A., & Bhat, P. (Eds.), Washington Manual of Medical Therapeutics. Available from https://www.unboundmedicine.com/washingtonmanual/view/Washington-Manual-of-Medical-Therapeutics/602038/all/Nausea
Nausea [Internet]. In: Williams D, Ramgopal R, Gdowski M, Dretler A, Bhat P, editors. Washington Manual of Medical Therapeutics. Wolters Kluwer Health; 2016. [cited 2019 July 20]. Available from: https://www.unboundmedicine.com/washingtonmanual/view/Washington-Manual-of-Medical-Therapeutics/602038/all/Nausea.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Nausea ID - 602038 ED - Williams,Dominique, ED - Ramgopal,Rajeev, ED - Gdowski,Mark, ED - Dretler,Alexandra, ED - Bhat,Pavat, BT - Washington Manual of Medical Therapeutics UR - https://www.unboundmedicine.com/washingtonmanual/view/Washington-Manual-of-Medical-Therapeutics/602038/all/Nausea PB - Wolters Kluwer Health ET - 35 DB - Washington Manual DP - Unbound Medicine ER -