Principles of Stem Cell Transplantation
Principles of Stem Cell Transplantation is a topic covered in the Washington Manual of Medical Therapeutics.
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Background
- Hematopoietic stem cell transplantation involves the infusion of either allogeneic or autologous stem cells, which is typically preceded by conditioning chemotherapy and sometimes total-body irradiation to clear residual disease and immunosuppress the recipient. Depending on the extent of myelosuppression achieved as a result of this conditioning, the regimens are classified as myeloablative, reduced intensity, or nonmyeloablative.
- Autologous transplantation involves collection, cryopreservation, and reinfusion of a patient’s own stem cells. This allows administration of myeloablative doses of chemotherapy with the intent of maximizing the efficacy of chemotherapy while rescuing hematopoiesis using stem cell re-infusion after chemotherapy.
- Allogeneic transplantation refers to the infusion of stem cells collected from either HLA-matched or mismatched donors. In addition to facilitating the administration of high doses of chemotherapy, allogeneic transplantation also allows for an immunologic effect mediated by donor T and natural killer cells on the tumor (graft-versus-tumor effect).
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Background
- Hematopoietic stem cell transplantation involves the infusion of either allogeneic or autologous stem cells, which is typically preceded by conditioning chemotherapy and sometimes total-body irradiation to clear residual disease and immunosuppress the recipient. Depending on the extent of myelosuppression achieved as a result of this conditioning, the regimens are classified as myeloablative, reduced intensity, or nonmyeloablative.
- Autologous transplantation involves collection, cryopreservation, and reinfusion of a patient’s own stem cells. This allows administration of myeloablative doses of chemotherapy with the intent of maximizing the efficacy of chemotherapy while rescuing hematopoiesis using stem cell re-infusion after chemotherapy.
- Allogeneic transplantation refers to the infusion of stem cells collected from either HLA-matched or mismatched donors. In addition to facilitating the administration of high doses of chemotherapy, allogeneic transplantation also allows for an immunologic effect mediated by donor T and natural killer cells on the tumor (graft-versus-tumor effect).
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Citation
Bhat, Pavat, et al., editors. "Principles of Stem Cell Transplantation." Washington Manual of Medical Therapeutics, 35th ed., Wolters Kluwer Health, 2016. Washington Manual Redesign, www.unboundmedicine.com/washingtonmanual/view/Washington-Manual-of-Medical-Therapeutics/602039/all/Principles_of_Stem_Cell_Transplantation.
Principles of Stem Cell Transplantation. In: Bhat PP, Dretler AA, Gdowski MM, et al, eds. Washington Manual of Medical Therapeutics. Wolters Kluwer Health; 2016. https://www.unboundmedicine.com/washingtonmanual/view/Washington-Manual-of-Medical-Therapeutics/602039/all/Principles_of_Stem_Cell_Transplantation. Accessed January 27, 2023.
Principles of Stem Cell Transplantation. (2016). In Bhat, P., Dretler, A., Gdowski, M., Ramgopal, R., & Williams, D. (Eds.), Washington Manual of Medical Therapeutics (35th ed.). Wolters Kluwer Health. https://www.unboundmedicine.com/washingtonmanual/view/Washington-Manual-of-Medical-Therapeutics/602039/all/Principles_of_Stem_Cell_Transplantation
Principles of Stem Cell Transplantation [Internet]. In: Bhat PP, Dretler AA, Gdowski MM, Ramgopal RR, Williams DD, editors. Washington Manual of Medical Therapeutics. Wolters Kluwer Health; 2016. [cited 2023 January 27]. Available from: https://www.unboundmedicine.com/washingtonmanual/view/Washington-Manual-of-Medical-Therapeutics/602039/all/Principles_of_Stem_Cell_Transplantation.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC
T1 - Principles of Stem Cell Transplantation
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ED - Williams,Dominique,
ED - Bhat,Pavat,
ED - Dretler,Alexandra,
ED - Gdowski,Mark,
ED - Ramgopal,Rajeev,
BT - Washington Manual of Medical Therapeutics
UR - https://www.unboundmedicine.com/washingtonmanual/view/Washington-Manual-of-Medical-Therapeutics/602039/all/Principles_of_Stem_Cell_Transplantation
PB - Wolters Kluwer Health
ET - 35
DB - Washington Manual Redesign
DP - Unbound Medicine
ER -