Principles of Stem Cell Transplantation
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- Hematopoietic stem cell transplantation involves the infusion of either allogeneic (different donor) or autologous (patient’s own) stem cells following administration of chemotherapy and/or radiation.
- Autologous transplantation involves collection, cryopreservation, and reinfusion of a patient’s own stem cells. This allows administration of myeloablative doses of chemotherapy with the intent of maximizing the efficacy of therapy.
- Allogeneic transplantation refers to the infusion of stem cells collected from either HLA-matched or mismatched donors. In addition to facilitating the administration of high doses of chemotherapy, allogeneic transplantation also allows for an immunologic effect mediated by donor T and natural killer cells (graft-versus-tumor effect).