The Washington Manual of Medical Therapeutics helps you diagnose and treat hundreds of medical conditions. Consult clinical recommendations from a resource that has been trusted on the wards for 50+ years. Explore these free sample topics:
-- The first section of this topic is shown below --
- FN is defined as an absolute neutrophil count (ANC) of <500/μL, with a single core temperature of >38.3°C or a persistent temperature (>1 hour) of >38.0°C.
- Risk of FN is proportional to the duration of neutropenia.
- Although most solid tumor chemotherapy regimens are associated with a brief (<5 days) duration of neutropenia, neutropenia with leukemia and transplantation regimens can be more persistent.
- Risk is also increased with regimens that cause mucositis (inflammation and ulceration of the oral and GI mucosa).