Nonalcoholic Fatty Liver Disease

Nonalcoholic Fatty Liver Disease is a topic covered in the Washington Manual of Medical Therapeutics.

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General Principles

  • Nonalcoholic fatty liver disease (NAFLD) is a clinicopathologic syndrome that encompasses several clinical entities that range from simple steatosis to steatohepatitis, fibrosis, ESLD, and HCC in the absence of significant alcohol consumption.
  • Nonalcoholic steatohepatitis (NASH) is part of the spectrum of NAFLD and is defined as the presence of hepatic steatosis and inflammation with hepatocyte injury (ballooning) with or without fibrosis.
  • NAFLD is associated with an increasing prevalence of type 2 diabetes, obesity, and the metabolic syndrome in the US population.
  • NAFLD has become one of the leading causes of liver transplantation in the United States.

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