General Principles

  • Blastomyces dermatitidis is dimorphic fungus that is endemic to the Ohio and Mississippi River valleys, as well as the Upper Midwestern, South Central, and Southeastern US.
  • The organism commonly disseminates, affecting the lungs, skin, bone, brain, and genitourinary tract. Aggressive pulmonary and CNS disease can occur in both immunocompromised and immunocompetent patients.

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