Fluoroquinolones

Fluoroquinolones is a topic covered in the Washington Manual of Medical Therapeutics.

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Washington Manual

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General Principles

  • Fluoroquinolones exert their bactericidal effect by inhibiting bacterial enzymes DNA gyrase and topoisomerase IV, which are critical for DNA replication. In general, these antibiotics are well absorbed orally, with serum concentrations that approach those of parenteral administration.
  • Concomitant administration with aluminum- or magnesium-containing antacids, sucralfate, bismuth, oral iron, oral calcium, oral zinc, and metallic cation-containing enteral nutrition preparations can markedly impair absorption of oral fluoroquinolones.

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