Mitral Regurgitation

Mitral Regurgitation is a topic covered in the Washington Manual of Medical Therapeutics.

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  • Prevention of MR is dependent on the integrated and proper function of the MV (annulus and leaflets), subvalvular apparatus (chordae tendineae and papillary muscles), LA, and LV; abnormal function or size of any one of these components can lead to MR.
  • Primary MR refers to MR caused primarily by lesions to the valve leaflets and/or chordae tendineae (i.e., myxomatous degeneration, endocarditis, rheumatic).
  • Secondary MR, or functional MR, refers to MR caused primarily by ventricular dysfunction usually with accompanying annular dilatation (i.e., dilated cardiomyopathy and ischemic MR).
  • It is critical to define the mechanism of MR and the time course (acute vs. chronic) because these significantly impact clinical management.

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  • Prevention of MR is dependent on the integrated and proper function of the MV (annulus and leaflets), subvalvular apparatus (chordae tendineae and papillary muscles), LA, and LV; abnormal function or size of any one of these components can lead to MR.
  • Primary MR refers to MR caused primarily by lesions to the valve leaflets and/or chordae tendineae (i.e., myxomatous degeneration, endocarditis, rheumatic).
  • Secondary MR, or functional MR, refers to MR caused primarily by ventricular dysfunction usually with accompanying annular dilatation (i.e., dilated cardiomyopathy and ischemic MR).
  • It is critical to define the mechanism of MR and the time course (acute vs. chronic) because these significantly impact clinical management.

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