Acquired Inhibitors of Coagulation Factors

Acquired Inhibitors of Coagulation Factors is a topic covered in the Washington Manual of Medical Therapeutics.

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General Principles

Acquired inhibitors of coagulation factors may occur de novo (autoantibodies) or may develop in hemophiliacs (alloantibodies) following factor VIII or IX infusions. Of the acquired inhibitors, those directed against factor VIII occur most commonly. De novo inhibitors often arise in patients who have underlying lymphoproliferative or autoimmune disorders.

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General Principles

Acquired inhibitors of coagulation factors may occur de novo (autoantibodies) or may develop in hemophiliacs (alloantibodies) following factor VIII or IX infusions. Of the acquired inhibitors, those directed against factor VIII occur most commonly. De novo inhibitors often arise in patients who have underlying lymphoproliferative or autoimmune disorders.

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