Pyrazinamide is a topic covered in the Washington Manual of Medical Therapeutics.

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Washington Manual

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General Principles

  • Pyrazinamide (15–30 mg/kg PO q24h [maximum, 2 g] or 50–75 mg/kg PO twice a week [maximum, 4 g/dose]) kills mycobacteria by an unknown disruption of membrane transport.
  • It is well absorbed orally and widely distributed throughout the body, including the CSF. Pyrazinamide is typically used for the first 2 months of therapy.

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