Deposition Disorders/Dysproteinemias

Deposition Disorders/Dysproteinemias is a topic covered in the Washington Manual of Medical Therapeutics.

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General Principles

Dysproteinemias—including those observed in multiple myeloma—include amyloidosis, light chain deposition disease (LCDD), and heavy chain deposition disease (HCDD). These disorders can affect the kidney in a variety of ways, including glomerular or tubular deposition, formation of insoluble protein casts in the tubules (micro-obstructive cast nephropathy), or through hypercalcemia and volume depletion. Glomerular deposition is typically associated with heavy proteinuria due to overflow as well as disruption of filtration barrier integrity.

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General Principles

Dysproteinemias—including those observed in multiple myeloma—include amyloidosis, light chain deposition disease (LCDD), and heavy chain deposition disease (HCDD). These disorders can affect the kidney in a variety of ways, including glomerular or tubular deposition, formation of insoluble protein casts in the tubules (micro-obstructive cast nephropathy), or through hypercalcemia and volume depletion. Glomerular deposition is typically associated with heavy proteinuria due to overflow as well as disruption of filtration barrier integrity.

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