The Washington Manual of Medical Therapeutics helps you diagnose and treat hundreds of medical conditions. Consult clinical recommendations from a resource that has been trusted on the wards for 50+ years. Explore these free sample topics:
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- Aplastic anemia (AA) is a disorder of hematopoietic stem cells that usually presents with pancytopenia.
- Most cases are acquired and idiopathic, but AA can also arise from an inherited BM failure syndrome such as Fanconi anemia, dyskeratosis congenita, and Shwachman–Diamond syndrome.
- Approximately 20% of cases may be associated with drug or chemical exposure (Table 21-5).Table 21-5: Commonly Used Drugs That Can Induce Red Blood Cell Disorders
Sideroblastic Anemia Aplastic Anemiaa G6PD Deficiency Immune Hemolytic Anemia Chloramphenicol
Cephalosporins (cefotetan, ceftriaxone)
Purine nucleoside analogues (fludarabine, cladribine)
NSAIDs (diclofenac, ibuprofen)
Data compiled from multiple sources. Agents listed are available in the United States.
a Drugs with ≥30 cases reported; many other drugs rarely are associated with aplastic anemia and are considered low risk.
G6PD, glucose-6-phosphate dehydrogenase.
- Approximately 10% of cases are associated with viral illnesses (e.g., viral hepatitis, Epstein–Barr virus, cytomegalovirus [CMV]).
- Clonal hematopoiesis is a feature of AA, with MDS and acute myeloid leukemia (AML) developing in ∼15% of patients.