Aplastic Anemia
Aplastic Anemia is a topic covered in the Washington Manual of Medical Therapeutics.
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General Principles
- Aplastic anemia (AA) is a disorder of hematopoietic stem cells that usually presents with pancytopenia.
- Most cases are acquired and idiopathic, but AA can also arise from an inherited BM failure syndrome such as Fanconi anemia, dyskeratosis congenita, and Shwachman–Diamond syndrome.
- Approximately 20% of cases may be associated with drug or chemical exposure.
- Approximately 10% of cases are associated with viral illnesses (e.g., viral hepatitis, Epstein–Barr virus, parvovirus, cytomegalovirus [CMV]).
- Clonal hematopoiesis is a feature of AA, with MDS and AML developing in ∼15% of patients.
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General Principles
- Aplastic anemia (AA) is a disorder of hematopoietic stem cells that usually presents with pancytopenia.
- Most cases are acquired and idiopathic, but AA can also arise from an inherited BM failure syndrome such as Fanconi anemia, dyskeratosis congenita, and Shwachman–Diamond syndrome.
- Approximately 20% of cases may be associated with drug or chemical exposure.
- Approximately 10% of cases are associated with viral illnesses (e.g., viral hepatitis, Epstein–Barr virus, parvovirus, cytomegalovirus [CMV]).
- Clonal hematopoiesis is a feature of AA, with MDS and AML developing in ∼15% of patients.
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Citation
Bhat, Pavat, et al., editors. "Aplastic Anemia." Washington Manual of Medical Therapeutics, 35th ed., Wolters Kluwer Health, 2016. The Washington Manual, www.unboundmedicine.com/washingtonmanual/view/Washington-Manual-of-Medical-Therapeutics/602150/all/Aplastic_Anemia.
Aplastic Anemia. In: Bhat PP, Dretler AA, Gdowski MM, et al, eds. Washington Manual of Medical Therapeutics. Wolters Kluwer Health; 2016. https://www.unboundmedicine.com/washingtonmanual/view/Washington-Manual-of-Medical-Therapeutics/602150/all/Aplastic_Anemia. Accessed February 9, 2023.
Aplastic Anemia. (2016). In Bhat, P., Dretler, A., Gdowski, M., Ramgopal, R., & Williams, D. (Eds.), Washington Manual of Medical Therapeutics (35th ed.). Wolters Kluwer Health. https://www.unboundmedicine.com/washingtonmanual/view/Washington-Manual-of-Medical-Therapeutics/602150/all/Aplastic_Anemia
Aplastic Anemia [Internet]. In: Bhat PP, Dretler AA, Gdowski MM, Ramgopal RR, Williams DD, editors. Washington Manual of Medical Therapeutics. Wolters Kluwer Health; 2016. [cited 2023 February 09]. Available from: https://www.unboundmedicine.com/washingtonmanual/view/Washington-Manual-of-Medical-Therapeutics/602150/all/Aplastic_Anemia.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC
T1 - Aplastic Anemia
ID - 602150
ED - Williams,Dominique,
ED - Bhat,Pavat,
ED - Dretler,Alexandra,
ED - Gdowski,Mark,
ED - Ramgopal,Rajeev,
BT - Washington Manual of Medical Therapeutics
UR - https://www.unboundmedicine.com/washingtonmanual/view/Washington-Manual-of-Medical-Therapeutics/602150/all/Aplastic_Anemia
PB - Wolters Kluwer Health
ET - 35
DB - The Washington Manual
DP - Unbound Medicine
ER -