Disseminated Intravascular Coagulation

Disseminated Intravascular Coagulation is a topic covered in the Washington Manual of Medical Therapeutics.

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General Principles

Etiology

DIC occurs in a variety of systemic illnesses that include sepsis, trauma, burns, shock, obstetric complications, and malignancies (notably, acute promyelocytic leukemia).

Pathophysiology

Exposure of tissue factor to the circulation generates excess thrombin, leading to platelet activation, consumption of coagulation factors (including fibrinogen) and regulators (antithrombin [AT] and proteins C and S), fibrin generation, generalized microthrombi, and reactive fibrinolysis.

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General Principles

Etiology

DIC occurs in a variety of systemic illnesses that include sepsis, trauma, burns, shock, obstetric complications, and malignancies (notably, acute promyelocytic leukemia).

Pathophysiology

Exposure of tissue factor to the circulation generates excess thrombin, leading to platelet activation, consumption of coagulation factors (including fibrinogen) and regulators (antithrombin [AT] and proteins C and S), fibrin generation, generalized microthrombi, and reactive fibrinolysis.

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