Washington Manual of Medical Therapeutics
Isoniazid
To view the entire topic, please sign in or purchase a subscription.
The Washington Manual of Medical Therapeutics helps you diagnose and treat hundreds of medical conditions. Consult clinical recommendations from a resource that has been trusted on the wards for 50+ years. Explore these free sample topics:
-- The first section of this topic is shown below --
General Principles
Isoniazid (INH; 300 mg PO q24h) exerts bactericidal effects by interfering with the synthesis of lipid components of the mycobacterial cell wall. INH is a component of most TB treatment regimens and can be given twice a week in directly observed therapy (15 mg/kg/dose; 900 mg maximum). INH remains the drug of choice for treatment of latent TB infection (300 mg PO q24h for 9 months, or combined with rifapentine in a 12-week regimen).
-- To view the remaining sections of this topic, please sign in or purchase a subscription --
General Principles
Isoniazid (INH; 300 mg PO q24h) exerts bactericidal effects by interfering with the synthesis of lipid components of the mycobacterial cell wall. INH is a component of most TB treatment regimens and can be given twice a week in directly observed therapy (15 mg/kg/dose; 900 mg maximum). INH remains the drug of choice for treatment of latent TB infection (300 mg PO q24h for 9 months, or combined with rifapentine in a 12-week regimen).
There's more to see -- the rest of this entry is available only to subscribers.
