Systemic Lupus Erythematosus

Systemic Lupus Erythematosus is a topic covered in the Washington Manual of Medical Therapeutics.

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General Principles

Definition

SLE is a multisystem disease of unknown etiology that primarily affects women of childbearing age. The female-to-male ratio is 9:1. It is most common in the second and third decades of life and in African Americans.

Pathophysiology

Pathophysiology is multifactorial and incompletely understood, with interplay of genetic predisposition and environmental factors.

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