Focal Segmental Glomerulosclerosis

Focal Segmental Glomerulosclerosis is a topic covered in the Washington Manual of Medical Therapeutics.

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General Principles

  • FSGS is not a single disease but rather a descriptive classification for diseases with shared histopathology. Presentation is with the nephrotic syndrome, hypertension, and renal insufficiency.
  • Secondary forms of FSGS are associated with obesity, vesicoureteral reflux, and HIV infection (FSGS of the collapsing variant). HIV can also induce secondary forms of other glomerular diseases such as MN and MPGN.

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General Principles

  • FSGS is not a single disease but rather a descriptive classification for diseases with shared histopathology. Presentation is with the nephrotic syndrome, hypertension, and renal insufficiency.
  • Secondary forms of FSGS are associated with obesity, vesicoureteral reflux, and HIV infection (FSGS of the collapsing variant). HIV can also induce secondary forms of other glomerular diseases such as MN and MPGN.

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