Focal Segmental Glomerulosclerosis

Focal Segmental Glomerulosclerosis is a topic covered in the Washington Manual of Medical Therapeutics.

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General Principles

  • FSGS is not a single disease but rather a pattern of glomerular injury with various mechanisms. It typically presents with nephrotic syndrome, hypertension, and sometimes renal insufficiency.
  • FSGS can be classified into primary (idiopathic) and secondary forms.1 Secondary forms of FSGS are associated with obesity, vesicoureteral reflux, sickle cell disease, medications (pamidronate, α-interferon, tyrosine kinase inhibitors), and infections (HIV, parvovirus, CMV, EBV).

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General Principles

  • FSGS is not a single disease but rather a pattern of glomerular injury with various mechanisms. It typically presents with nephrotic syndrome, hypertension, and sometimes renal insufficiency.
  • FSGS can be classified into primary (idiopathic) and secondary forms.1 Secondary forms of FSGS are associated with obesity, vesicoureteral reflux, sickle cell disease, medications (pamidronate, α-interferon, tyrosine kinase inhibitors), and infections (HIV, parvovirus, CMV, EBV).

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