Malignant Hypercalcemia

Malignant Hypercalcemia is a topic covered in the Washington Manual of Medical Therapeutics.

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Washington Manual

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  • Malignant hypercalcemia is a common paraneoplastic syndrome and occurs in nearly 10%–20% of cancer patients.
  • A serum total calcium level of >10.5 g/dL is generally considered elevated. Measuring ionized calcium can be necessary and helpful in patients with abnormal serum albumin levels.
  • Osteolysis and humoral hypercalcemia through tumor production of parathyroid hormone (PTH), PTH-related protein (PTHrP), or vitamin D analogues are the predominant mechanisms of hypercalcemia.

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