The Washington Manual of Medical Therapeutics helps you diagnose and treat hundreds of medical conditions. Consult clinical recommendations from a resource that has been trusted on the wards for 50+ years. Explore these free sample topics:
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- Celiac sprue consists of chronic inflammation of proximal small bowel mucosa from an immunologic sensitivity to gluten (protein found in wheat, barley, and rye), resulting in malabsorption of dietary nutrients.
- Clinical presentation can vary greatly from asymptomatic iron deficiency anemia to significant diarrhea and weight loss. Other presenting features can include osteoporosis, dermatitis herpetiformis, abnormal liver enzymes, and abdominal pain; incidental recognition at endoscopy can also occur (N Engl J Med 2007;357:1731 [PMID:17960014]).
- More than 7% of patients with nonconstipated IBS have celiac-associated antibodies, suggesting that gluten sensitivity may trigger symptoms resembling IBS (Gastroenterology 2011;141:1187 [PMID:21762658]).