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Celiac Sprue

Celiac Sprue is a topic covered in the Washington Manual of Medical Therapeutics.

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General Principles

  • Celiac sprue consists of chronic inflammation of proximal small bowel mucosa from an immunologic sensitivity to gluten (protein found in wheat, barley, and rye), resulting in malabsorption of dietary nutrients.
  • Clinical presentation can vary greatly from asymptomatic iron deficiency anemia to significant diarrhea and weight loss. Other presenting features can include osteoporosis, dermatitis herpetiformis, abnormal liver enzymes, and abdominal pain; incidental recognition at endoscopy can also occur (N Engl J Med 2007;357:1731  [PMID:17960014]).
  • More than 7% of patients with nonconstipated IBS have celiac-associated antibodies, suggesting that gluten sensitivity may trigger symptoms resembling IBS (Gastroenterology 2011;141:1187  [PMID:21762658]).

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Williams, Dominique, et al., editors. "Celiac Sprue." Washington Manual of Medical Therapeutics, 35th ed., Wolters Kluwer Health, 2016. Washington Manual, www.unboundmedicine.com/washingtonmanual/view/Washington-Manual-of-Medical-Therapeutics/602243/all/Celiac_Sprue.
Celiac Sprue. In: Williams D, Ramgopal R, Gdowski M, et al, eds. Washington Manual of Medical Therapeutics. 35th ed. Wolters Kluwer Health; 2016. https://www.unboundmedicine.com/washingtonmanual/view/Washington-Manual-of-Medical-Therapeutics/602243/all/Celiac_Sprue. Accessed June 20, 2019.
Celiac Sprue. (2016). In Williams, D., Ramgopal, R., Gdowski, M., Dretler, A., & Bhat, P. (Eds.), Washington Manual of Medical Therapeutics. Available from https://www.unboundmedicine.com/washingtonmanual/view/Washington-Manual-of-Medical-Therapeutics/602243/all/Celiac_Sprue
Celiac Sprue [Internet]. In: Williams D, Ramgopal R, Gdowski M, Dretler A, Bhat P, editors. Washington Manual of Medical Therapeutics. Wolters Kluwer Health; 2016. [cited 2019 June 20]. Available from: https://www.unboundmedicine.com/washingtonmanual/view/Washington-Manual-of-Medical-Therapeutics/602243/all/Celiac_Sprue.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Celiac Sprue ID - 602243 ED - Williams,Dominique, ED - Ramgopal,Rajeev, ED - Gdowski,Mark, ED - Dretler,Alexandra, ED - Bhat,Pavat, BT - Washington Manual of Medical Therapeutics UR - https://www.unboundmedicine.com/washingtonmanual/view/Washington-Manual-of-Medical-Therapeutics/602243/all/Celiac_Sprue PB - Wolters Kluwer Health ET - 35 DB - Washington Manual DP - Unbound Medicine ER -