Aspergillosis is a topic covered in the Washington Manual of Medical Therapeutics.

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General Principles

  • Aspergillus species are ubiquitous environmental fungi that cause a broad spectrum of disease, usually affecting the respiratory system and sinuses.
  • Pulmonary aspergillomas arise in the setting of preexisting bullous lung disease and are easily recognized by characteristic radiographic presentation and Aspergillus serology.
  • Invasive aspergillosis (IA) is a serious condition associated with vascular invasion, thrombosis, and ischemic infarction of involved tissues and progressive disease after hematogenous dissemination. IA is usually seen in severely immunocompromised patients, especially allogeneic hematopoietic stem cell transplant recipients (HSCT).
  • Allergic bronchopulmonary aspergillosis is a chronic relapsing and remitting respiratory syndrome associated with Aspergillus colonization.

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