Telavancin

Telavancin is a topic covered in the Washington Manual of Medical Therapeutics.

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General Principles

Telavancin (7.5–10 mg/kg q24–48h, based on CrCl) is a lipoglycopeptide antibiotic that is FDA approved for treatment of hospital-acquired and ventilator-associated bacterial pneumonia caused by S. aureus and for complicated skin and skin structure infections. Telavancin is broadly active against gram-positive bacteria, including MRSA, VISA, heteroresistant VISA (hVISA), daptomycin- and linezolid-resistant S. aureus, streptococci, vancomycin-sensitive enterococci, and some gram-positive anaerobes. The agent is not active against gram-negative bacteria, vancomycin-resistant S. aureus, and VRE.

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