Washington Manual of Medical Therapeutics
Drug-Induced Liver Injury
General Principles
- The National Institutes of Health maintains a searchable database of over 1000 drugs, herbal medications, and dietary supplements that have been associated with drug-induced liver injury (DILI) at http://livertox.nih.gov/.
- There are three major classifications of DILI that occur as a result of both intrinsic and idiosyncratic hepatotoxicity: hepatocellular, cholestatic, or mixed.
- DILI is responsible for approximately 50% of all cases of ALF in the US, with acetaminophen being the most common causative agent. Acute DILI (<3 months) progresses to chronic injury in 5%–10% of cases.1
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Citation
Bhat, Pavat, et al., editors. "Drug-Induced Liver Injury." Washington Manual of Medical Therapeutics, 35th ed., Wolters Kluwer Health, 2016. The Washington Manual, www.unboundmedicine.com/washingtonmanual/view/Washington-Manual-of-Medical-Therapeutics/602267/all/Drug_Induced_Liver_Injury.
Drug-Induced Liver Injury. In: Bhat PP, Dretler AA, Gdowski MM, et al, eds. Washington Manual of Medical Therapeutics. Wolters Kluwer Health; 2016. https://www.unboundmedicine.com/washingtonmanual/view/Washington-Manual-of-Medical-Therapeutics/602267/all/Drug_Induced_Liver_Injury. Accessed June 10, 2023.
Drug-Induced Liver Injury. (2016). In Bhat, P., Dretler, A., Gdowski, M., Ramgopal, R., & Williams, D. (Eds.), Washington Manual of Medical Therapeutics (35th ed.). Wolters Kluwer Health. https://www.unboundmedicine.com/washingtonmanual/view/Washington-Manual-of-Medical-Therapeutics/602267/all/Drug_Induced_Liver_Injury
Drug-Induced Liver Injury [Internet]. In: Bhat PP, Dretler AA, Gdowski MM, Ramgopal RR, Williams DD, editors. Washington Manual of Medical Therapeutics. Wolters Kluwer Health; 2016. [cited 2023 June 10]. Available from: https://www.unboundmedicine.com/washingtonmanual/view/Washington-Manual-of-Medical-Therapeutics/602267/all/Drug_Induced_Liver_Injury.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC
T1 - Drug-Induced Liver Injury
ID - 602267
ED - Williams,Dominique,
ED - Bhat,Pavat,
ED - Dretler,Alexandra,
ED - Gdowski,Mark,
ED - Ramgopal,Rajeev,
BT - Washington Manual of Medical Therapeutics
UR - https://www.unboundmedicine.com/washingtonmanual/view/Washington-Manual-of-Medical-Therapeutics/602267/all/Drug_Induced_Liver_Injury
PB - Wolters Kluwer Health
ET - 35
DB - The Washington Manual
DP - Unbound Medicine
ER -
