Drug-Induced Liver Injury

General Principles

  • The National Institutes of Health maintains a searchable database of over 1000 drugs, herbal medications, and dietary supplements that have been associated with drug-induced liver injury (DILI) at http://livertox.nih.gov/.
  • There are three major classifications of DILI that occur as a result of both intrinsic and idiosyncratic hepatotoxicity: hepatocellular, cholestatic, or mixed.
  • DILI is responsible for approximately 50% of all cases of ALF in the US, with acetaminophen being the most common causative agent. Acute DILI (<3 months) progresses to chronic injury in 5%–10% of cases.1

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