Amyloidosis is a topic covered in the Washington Manual of Medical Therapeutics.

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General Principles

Primary (AL) amyloidosis is an infiltrative disorder due to monoclonal, light chain deposition in various tissues most often involving the kidney (renal failure, nephrotic syndrome), heart (nonischemic cardiomyopathy), peripheral nervous system (neuropathy), and GI tract/liver (macroglossia, diarrhea, nausea, vomiting). Unexplained findings in any of these organ systems should prompt evaluation for amyloidosis. Primary amyloidosis must be distinguished from nonclonal secondary systemic amyloidosis.1

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