Colorectal Cancer

Colorectal Cancer is a topic covered in the Washington Manual of Medical Therapeutics.

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Epidemiology and Etiology

Colorectal cancer is the third most common malignancy worldwide. The incidence is higher in Western industrialized countries, with 97,220 cases estimated to be diagnosed in the United States in 2018. Although the incidence of colorectal cancer in adults aged 50 or older is declining, largely because of screening colonoscopy, the incidence among young adults (aged 20–49) has increased over the last few decades. Risk factors include age >50, physical inactivity, obesity, diet with increased red meat and decreased fiber, personal history of polyps or colorectal cancer, inflammatory bowel disease, and hereditary syndromes such as Lynch syndrome and familial adenomatous polyposis.

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