Candidiasis is a topic covered in the Washington Manual of Medical Therapeutics.

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General Principles

  • Candida species are the most common cause of invasive fungal infections in humans.
  • Infections ranging from uncomplicated mucosal disease to life-threatening invasive disease affecting any organ can occur. Infections are often associated with concurrent antibiotic use, contraceptive use, immunosuppressant and cytotoxic therapy, and indwelling foreign bodies. Mucocutaneous disease may resolve after elimination of the causative condition (e.g., antibiotic therapy) or may persist and progress in the setting of immunosuppressive conditions.
  • In the United States, Candida is the fourth most common cause of bloodstream infection (BSI) overall, and the leading cause of nosocomial BSI. Serious complications of candidemia include skin lesions, ocular disease, endocarditis, and osteomyelitis.1

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