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Penicillins

Penicillins is a topic covered in the Washington Manual of Medical Therapeutics.

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General Principles

  • Penicillins (PCNs) irreversibly bind PCN-binding proteins in the bacterial cell wall, causing osmotic rupture and death. Acquired resistance in many bacterial species through alterations in PCN-binding proteins or expression of hydrolytic enzymes has limited their use.
  • PCNs remain among the drugs of choice for syphilis and infections caused by PCN-sensitive streptococci, methicillin-sensitive Staphylococcus aureus (MSSA), Listeria monocytogenes, Pasteurella multocida, and Actinomyces.

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Citation

Williams, Dominique, et al., editors. "Penicillins." Washington Manual of Medical Therapeutics, 35th ed., Wolters Kluwer Health, 2016. Washington Manual, www.unboundmedicine.com/washingtonmanual/view/Washington-Manual-of-Medical-Therapeutics/602328/all/Penicillins.
Penicillins. In: Williams D, Ramgopal R, Gdowski M, et al, eds. Washington Manual of Medical Therapeutics. 35th ed. Wolters Kluwer Health; 2016. https://www.unboundmedicine.com/washingtonmanual/view/Washington-Manual-of-Medical-Therapeutics/602328/all/Penicillins. Accessed July 20, 2019.
Penicillins. (2016). In Williams, D., Ramgopal, R., Gdowski, M., Dretler, A., & Bhat, P. (Eds.), Washington Manual of Medical Therapeutics. Available from https://www.unboundmedicine.com/washingtonmanual/view/Washington-Manual-of-Medical-Therapeutics/602328/all/Penicillins
Penicillins [Internet]. In: Williams D, Ramgopal R, Gdowski M, Dretler A, Bhat P, editors. Washington Manual of Medical Therapeutics. Wolters Kluwer Health; 2016. [cited 2019 July 20]. Available from: https://www.unboundmedicine.com/washingtonmanual/view/Washington-Manual-of-Medical-Therapeutics/602328/all/Penicillins.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Penicillins ID - 602328 ED - Williams,Dominique, ED - Ramgopal,Rajeev, ED - Gdowski,Mark, ED - Dretler,Alexandra, ED - Bhat,Pavat, BT - Washington Manual of Medical Therapeutics UR - https://www.unboundmedicine.com/washingtonmanual/view/Washington-Manual-of-Medical-Therapeutics/602328/all/Penicillins PB - Wolters Kluwer Health ET - 35 DB - Washington Manual DP - Unbound Medicine ER -