Minimal Change Disease

Minimal Change Disease is a topic covered in the Washington Manual of Medical Therapeutics.

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General Principles

Epidemiology

MCD is the most common cause of the nephrotic syndrome in children but has a second peak in adults aged 50–60 years. Typically, there is sudden onset of proteinuria with hypertension and edema as well as the full nephrotic syndrome, although renal insufficiency is unusual.

Associated Conditions

Secondary forms of MCD may accompany certain malignancies (Hodgkin disease and solid tumors being the most common). A form of interstitial nephritis associated with NSAID use may also be associated with MCD.

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General Principles

Epidemiology

MCD is the most common cause of the nephrotic syndrome in children but has a second peak in adults aged 50–60 years. Typically, there is sudden onset of proteinuria with hypertension and edema as well as the full nephrotic syndrome, although renal insufficiency is unusual.

Associated Conditions

Secondary forms of MCD may accompany certain malignancies (Hodgkin disease and solid tumors being the most common). A form of interstitial nephritis associated with NSAID use may also be associated with MCD.

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