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Diarrhea

Diarrhea is a topic covered in the Washington Manual of Medical Therapeutics.

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Washington Manual

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  • Diarrhea is a common side effect of many chemotherapies (irinotecan, 5FU, capecitabine), targeted agents (erlotinib, cetuximab, sunitinib, lapatinib), and newer immunotherapies (ipilimumab, nivolumab, pembrolizumab).
  • Diarrhea can also be a symptomatic manifestation of the underlying cancer (such as carcinoid syndrome in neuroendocrine tumors).
  • Obtaining a good history and accurately assessing the type of cancer a patient has, treatments received and their timing, history of bone marrow transplantation (GVHD), immunosuppressant regimen, recent dose adjustments, and recent antibiotic use are all very crucial.
  • Imaging of the abdomen, Clostridium difficile testing, and even obtaining a colonoscopy might be required in selected patients (e.g., ipilimumab-related colitis).
  • Special attention should be paid to transplant patients because testing serum levels of immunosuppressants and testing for opportunistic infections constitute an important part of workup.

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Citation

Williams, Dominique, et al., editors. "Diarrhea." Washington Manual of Medical Therapeutics, 35th ed., Wolters Kluwer Health, 2016. Washington Manual, www.unboundmedicine.com/washingtonmanual/view/Washington-Manual-of-Medical-Therapeutics/602349/all/Diarrhea.
Diarrhea. In: Williams D, Ramgopal R, Gdowski M, et al, eds. Washington Manual of Medical Therapeutics. 35th ed. Wolters Kluwer Health; 2016. https://www.unboundmedicine.com/washingtonmanual/view/Washington-Manual-of-Medical-Therapeutics/602349/all/Diarrhea. Accessed July 19, 2019.
Diarrhea. (2016). In Williams, D., Ramgopal, R., Gdowski, M., Dretler, A., & Bhat, P. (Eds.), Washington Manual of Medical Therapeutics. Available from https://www.unboundmedicine.com/washingtonmanual/view/Washington-Manual-of-Medical-Therapeutics/602349/all/Diarrhea
Diarrhea [Internet]. In: Williams D, Ramgopal R, Gdowski M, Dretler A, Bhat P, editors. Washington Manual of Medical Therapeutics. Wolters Kluwer Health; 2016. [cited 2019 July 19]. Available from: https://www.unboundmedicine.com/washingtonmanual/view/Washington-Manual-of-Medical-Therapeutics/602349/all/Diarrhea.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Diarrhea ID - 602349 ED - Williams,Dominique, ED - Ramgopal,Rajeev, ED - Gdowski,Mark, ED - Dretler,Alexandra, ED - Bhat,Pavat, BT - Washington Manual of Medical Therapeutics UR - https://www.unboundmedicine.com/washingtonmanual/view/Washington-Manual-of-Medical-Therapeutics/602349/all/Diarrhea PB - Wolters Kluwer Health ET - 35 DB - Washington Manual DP - Unbound Medicine ER -