Phosphorus

Phosphorus is a topic covered in the Washington Manual of Medical Therapeutics.

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  • Phosphorus is critical for bone formation and cellular energy metabolism.
  • Approximately 85% of total body phosphorus is in bone, and most of the remainder is within cells. Thus, serum phosphorus levels may not reflect total body phosphorus stores.
  • Phosphorus balance is determined primarily by four factors:
    • PTH regulates the incorporation and release of minerals from bone stores and decreases proximal tubular reabsorption of phosphate, causing urinary wasting.
    • The phosphate concentration itself regulates renal proximal reabsorption.
    • Insulin lowers serum levels by shifting phosphate into cells.
    • Calcitriol [1,25(OH)2D3] increases serum phosphate by enhancing intestinal phosphorus absorption.

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  • Phosphorus is critical for bone formation and cellular energy metabolism.
  • Approximately 85% of total body phosphorus is in bone, and most of the remainder is within cells. Thus, serum phosphorus levels may not reflect total body phosphorus stores.
  • Phosphorus balance is determined primarily by four factors:
    • PTH regulates the incorporation and release of minerals from bone stores and decreases proximal tubular reabsorption of phosphate, causing urinary wasting.
    • The phosphate concentration itself regulates renal proximal reabsorption.
    • Insulin lowers serum levels by shifting phosphate into cells.
    • Calcitriol [1,25(OH)2D3] increases serum phosphate by enhancing intestinal phosphorus absorption.

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