Sideroblastic Anemias

General Principles


Sideroblastic anemias are hereditary or acquired RBC disorders characterized by abnormal iron metabolism associated with the presence of ring sideroblasts (RS) in the developing RBCs in the BM.


  • Acquired
    • Primary sideroblastic anemia (myelodysplastic syndrome with ring sideroblasts [MDS-RS] or myelodysplastic/myeloproliferative neoplasms with ring sideroblasts [MDS/MPN-RS]).
    • Secondary sideroblastic anemia is caused by drugs (i.e., chloramphenicol, cycloserine, ethanol, isoniazid, pyrazinamide), lead or zinc toxicity, chronic alcohol use, or copper deficiency.
  • Hereditary
    • X-linked
    • Autosomal
    • Mitochondrial

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