Sideroblastic Anemias

Sideroblastic Anemias is a topic covered in the Washington Manual of Medical Therapeutics.

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General Principles

Definition

Sideroblastic anemias are hereditary or acquired RBC disorders characterized by abnormal iron metabolism associated with the presence of ring sideroblasts in the developing RBCs in the BM.

Etiology

  • Acquired
    • Primary sideroblastic anemia (myelodysplastic syndrome [MDS])
    • Secondary sideroblastic anemia is caused by drugs (i.e., chloramphenicol, cycloserine, ethanol, isoniazid, pyrazinamide), lead or zinc toxicity, chronic ethanol use, or copper deficiency
  • Hereditary
    • X-linked
    • Autosomal
    • Mitochondrial

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General Principles

Definition

Sideroblastic anemias are hereditary or acquired RBC disorders characterized by abnormal iron metabolism associated with the presence of ring sideroblasts in the developing RBCs in the BM.

Etiology

  • Acquired
    • Primary sideroblastic anemia (myelodysplastic syndrome [MDS])
    • Secondary sideroblastic anemia is caused by drugs (i.e., chloramphenicol, cycloserine, ethanol, isoniazid, pyrazinamide), lead or zinc toxicity, chronic ethanol use, or copper deficiency
  • Hereditary
    • X-linked
    • Autosomal
    • Mitochondrial

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