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Quinupristin/Dalfopristin is a topic covered in the Washington Manual of Medical Therapeutics.

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General Principles

  • Quinupristin/dalfopristin (7.5 mg/kg IV q8h) is the first FDA-approved drug in the streptogramin class.
  • This agent has activity against antibiotic-resistant gram-positive organisms, especially VRE, MRSA, and antibiotic-resistant strains of Streptococcus pneumoniae. It has some activity against gram-negative upper respiratory pathogens (Haemophilus and Moraxella) and anaerobes, but more appropriate antibiotics are available to treat these infections. Quinupristin/dalfopristin is bacteriostatic for enterococci and can be used for treatment of serious infections with VRE (only E. faecium because it is inactive against E. faecalis).

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Williams, Dominique, et al., editors. "Quinupristin/Dalfopristin." Washington Manual of Medical Therapeutics, 35th ed., Wolters Kluwer Health, 2016. Washington Manual, www.unboundmedicine.com/washingtonmanual/view/Washington-Manual-of-Medical-Therapeutics/602387/all/Quinupristin_Dalfopristin.
Quinupristin/Dalfopristin. In: Williams D, Ramgopal R, Gdowski M, et al, eds. Washington Manual of Medical Therapeutics. 35th ed. Wolters Kluwer Health; 2016. https://www.unboundmedicine.com/washingtonmanual/view/Washington-Manual-of-Medical-Therapeutics/602387/all/Quinupristin_Dalfopristin. Accessed August 17, 2019.
Quinupristin/Dalfopristin. (2016). In Williams, D., Ramgopal, R., Gdowski, M., Dretler, A., & Bhat, P. (Eds.), Washington Manual of Medical Therapeutics. Available from https://www.unboundmedicine.com/washingtonmanual/view/Washington-Manual-of-Medical-Therapeutics/602387/all/Quinupristin_Dalfopristin
Quinupristin/Dalfopristin [Internet]. In: Williams D, Ramgopal R, Gdowski M, Dretler A, Bhat P, editors. Washington Manual of Medical Therapeutics. Wolters Kluwer Health; 2016. [cited 2019 August 17]. Available from: https://www.unboundmedicine.com/washingtonmanual/view/Washington-Manual-of-Medical-Therapeutics/602387/all/Quinupristin_Dalfopristin.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Quinupristin/Dalfopristin ID - 602387 ED - Williams,Dominique, ED - Ramgopal,Rajeev, ED - Gdowski,Mark, ED - Dretler,Alexandra, ED - Bhat,Pavat, BT - Washington Manual of Medical Therapeutics UR - https://www.unboundmedicine.com/washingtonmanual/view/Washington-Manual-of-Medical-Therapeutics/602387/all/Quinupristin_Dalfopristin PB - Wolters Kluwer Health ET - 35 DB - Washington Manual DP - Unbound Medicine ER -