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Tumor Lysis Syndrome

Tumor Lysis Syndrome is a topic covered in the Washington Manual of Medical Therapeutics.

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  • TLS is a group of metabolic disturbances resulting from significant tumor breakdown with release of intracellular products into circulation.
  • TLS occurs in tumors that grow rapidly and are sensitive to cytotoxic chemotherapy. The risk of TLS is high in patients with acute leukemias and high-grade lymphomas, bulky tumors, elevated pretreatment LDH and uric acid levels, and renal dysfunction.
  • TLS can also be spontaneous (not treatment related).
  • Certain medications such as venetoclax are associated with the development of TLS at treatment and warrant close surveillance.

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Williams, Dominique, et al., editors. "Tumor Lysis Syndrome." Washington Manual of Medical Therapeutics, 35th ed., Wolters Kluwer Health, 2016. Washington Manual, www.unboundmedicine.com/washingtonmanual/view/Washington-Manual-of-Medical-Therapeutics/602471/all/Tumor_Lysis_Syndrome.
Tumor Lysis Syndrome. In: Williams D, Ramgopal R, Gdowski M, et al, eds. Washington Manual of Medical Therapeutics. 35th ed. Wolters Kluwer Health; 2016. https://www.unboundmedicine.com/washingtonmanual/view/Washington-Manual-of-Medical-Therapeutics/602471/all/Tumor_Lysis_Syndrome. Accessed July 19, 2019.
Tumor Lysis Syndrome. (2016). In Williams, D., Ramgopal, R., Gdowski, M., Dretler, A., & Bhat, P. (Eds.), Washington Manual of Medical Therapeutics. Available from https://www.unboundmedicine.com/washingtonmanual/view/Washington-Manual-of-Medical-Therapeutics/602471/all/Tumor_Lysis_Syndrome
Tumor Lysis Syndrome [Internet]. In: Williams D, Ramgopal R, Gdowski M, Dretler A, Bhat P, editors. Washington Manual of Medical Therapeutics. Wolters Kluwer Health; 2016. [cited 2019 July 19]. Available from: https://www.unboundmedicine.com/washingtonmanual/view/Washington-Manual-of-Medical-Therapeutics/602471/all/Tumor_Lysis_Syndrome.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Tumor Lysis Syndrome ID - 602471 ED - Williams,Dominique, ED - Ramgopal,Rajeev, ED - Gdowski,Mark, ED - Dretler,Alexandra, ED - Bhat,Pavat, BT - Washington Manual of Medical Therapeutics UR - https://www.unboundmedicine.com/washingtonmanual/view/Washington-Manual-of-Medical-Therapeutics/602471/all/Tumor_Lysis_Syndrome PB - Wolters Kluwer Health ET - 35 DB - Washington Manual DP - Unbound Medicine ER -