Tumor Lysis Syndrome
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- TLS is a group of metabolic disturbances resulting from significant tumor breakdown with release of intracellular products into circulation.
- TLS occurs in tumors that grow rapidly and are sensitive to cytotoxic chemotherapy. The risk of TLS is high in patients with acute leukemias and high-grade lymphomas, bulky tumors, elevated pretreatment LDH and uric acid levels, and renal dysfunction.
- TLS can also be spontaneous (not treatment related).
- Certain medications such as venetoclax are associated with the development of TLS at treatment and warrant close surveillance.