Tetracyclines is a topic covered in the Washington Manual of Medical Therapeutics.

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General Principles

  • Tetracyclines are bacteriostatic antibiotics that bind to the 30S ribosomal subunit and block protein synthesis.
  • These agents have unique roles in the treatment of Rickettsia, Ehrlichia, Chlamydia, and Mycoplasma infections. They are used as therapy for most tick-borne infections and Lyme disease–related arthritis, alternate therapy for syphilis, and therapy for P. multocida infections in PCN-allergic patients. Minocycline and doxycycline also have activity against some multidrug-resistant gram-negative pathogens and may be used in this setting based on results of susceptibility testing.

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