Tetracyclines
Tetracyclines is a topic covered in the Washington Manual of Medical Therapeutics.
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General Principles
- Tetracyclines are bacteriostatic antibiotics that bind to the 30S ribosomal subunit and block protein synthesis.
- These agents have unique roles in the treatment of Rickettsia, Ehrlichia, Chlamydia, and Mycoplasma infections. They are used as therapy for most tick-borne infections, including Lyme disease–related arthritis, alternate therapy for syphilis, and therapy for P. multocida infections in PCN-allergic patients. The tetracycline derivatives also have activity against some multidrug-resistant (MDR) gram-negative pathogens and may be used in this setting based on results of susceptibility testing.
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General Principles
- Tetracyclines are bacteriostatic antibiotics that bind to the 30S ribosomal subunit and block protein synthesis.
- These agents have unique roles in the treatment of Rickettsia, Ehrlichia, Chlamydia, and Mycoplasma infections. They are used as therapy for most tick-borne infections, including Lyme disease–related arthritis, alternate therapy for syphilis, and therapy for P. multocida infections in PCN-allergic patients. The tetracycline derivatives also have activity against some multidrug-resistant (MDR) gram-negative pathogens and may be used in this setting based on results of susceptibility testing.
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Citation
Bhat, Pavat, et al., editors. "Tetracyclines." Washington Manual of Medical Therapeutics, 35th ed., Wolters Kluwer Health, 2016. The Washington Manual, www.unboundmedicine.com/washingtonmanual/view/Washington-Manual-of-Medical-Therapeutics/602477/all/Tetracyclines.
Tetracyclines. In: Bhat PP, Dretler AA, Gdowski MM, et al, eds. Washington Manual of Medical Therapeutics. Wolters Kluwer Health; 2016. https://www.unboundmedicine.com/washingtonmanual/view/Washington-Manual-of-Medical-Therapeutics/602477/all/Tetracyclines. Accessed February 1, 2023.
Tetracyclines. (2016). In Bhat, P., Dretler, A., Gdowski, M., Ramgopal, R., & Williams, D. (Eds.), Washington Manual of Medical Therapeutics (35th ed.). Wolters Kluwer Health. https://www.unboundmedicine.com/washingtonmanual/view/Washington-Manual-of-Medical-Therapeutics/602477/all/Tetracyclines
Tetracyclines [Internet]. In: Bhat PP, Dretler AA, Gdowski MM, Ramgopal RR, Williams DD, editors. Washington Manual of Medical Therapeutics. Wolters Kluwer Health; 2016. [cited 2023 February 01]. Available from: https://www.unboundmedicine.com/washingtonmanual/view/Washington-Manual-of-Medical-Therapeutics/602477/all/Tetracyclines.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC
T1 - Tetracyclines
ID - 602477
ED - Williams,Dominique,
ED - Bhat,Pavat,
ED - Dretler,Alexandra,
ED - Gdowski,Mark,
ED - Ramgopal,Rajeev,
BT - Washington Manual of Medical Therapeutics
UR - https://www.unboundmedicine.com/washingtonmanual/view/Washington-Manual-of-Medical-Therapeutics/602477/all/Tetracyclines
PB - Wolters Kluwer Health
ET - 35
DB - The Washington Manual
DP - Unbound Medicine
ER -