Monoclonal Gammopathy of Unknown Significance

Monoclonal Gammopathy of Unknown Significance is a topic covered in the Washington Manual of Medical Therapeutics.

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General Principles

Definition

Monoclonal gammopathy of unknown significance (MGUS) is a commonly occurring premalignant condition characterized by the presence of a small (<10%) population of neoplastic, clonal plasma cells or lymphoplasmacytic cells in the BM that occurs in the absence of any end-organ damage. For non-IgM MGUS, progression to a more serious disorder including multiple myeloma, WM, or primary amyloidosis (AL) occurs at a rate of approximately 1% per year. For IgM MGUS, progression to WM or primary AL amyloidosis occurs at a rate of 1%–5% per year.

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